WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. WebArticle Snippet: Wang et al. [ ] reported that cisplatin-resistant T24/DDP was produced via stepwise exposure to escalating concentrations (0.2 μg/ml to 2.0 μg/ml) of DDP (Selleck, USA) for >6 months. Techniques: Over Expression, Expressing, Transfection, Plasmid Preparation, MTT Assay, Sublimation, Flow Cytometry, Negative Control.

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WebCisplatin is a platinum-containing, broad activity antineoplastic and alkylating agent effective against solid tumors of testes, ovaries, and bladder; epithelial malignancies; and cancers of the esophagus, lung, head, and neck.1,3,4 Cisplatin is effective against sarcoma and leukemia in mice.5 Cisplatin enters cells by diffusion. WebOct 29, 2024 · The expression of metallothioneins (MT) has been identified as a reason for cisplatin resistance, which often leads to early therapy failure or relapse. Thus, knockdown of MT expression may... lymphatic cleansing and brushing

Impact of metallothionein-knockdown on cisplatin resistance in

WebThe cisplatin resistant phenotype, OVCAR3cis, cells were cultured with 1 µM cisplatin (SelleckChem, Houston, TX, USA). The endometrial subtype OC cell lines A2780 and A2780cis, were cultured in RPMI 1640, supplemented with 10% fetal bovine serum, 2 mM L-glutamine and Primocin TM. The cisplatin resistant phenotype, A2780cis, cells were … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … lymphatic cleansing process